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Hyaluronic acid dermal fillers are injection treatments used to diminish wrinkles, restore fullness, or make subtle changes. Hyaluronic acid (HA) is a naturally occurring substance in your skin that helps provide hydration, fullness, and elasticity. It diminishes as we age, causing skin to lose volume while increasing the chances for wrinkles and folds to appear. Restylane dermal fillers use clear gel formulations of HA. As the original non-animal stabilized HA filler, Restylane was designed to be closest to the body's own hyaluronic acid with minimal crosslinking and was the first to be approved by the US FDA.